Kim Kardashian has hit back at her former brother-in-law Lamar Odom after he said he knew his marriage to her sister Khloe was over “when she was on her second or third NBA player”.

Kardashian retaliated on Twitter, saying: “Or second or third brothel.”

Odom had been discussing his failed marriage to reality star Khloe Kardashian on the show Mancave on US network BET.

In a preview clip of the programme, he said: “I still got my shawty’s name still on me — I mean, her initials still on me. For no reason.

“I understand when it’s over, it’s over. When she was with her second or third NBA ball player, I could see that.”

Kardashian defended her sister in response to a Twitter user who shared the quote alongside the comment: “Burn!”

In October 2015, Odom was rushed to the hospital after being found unconscious in a Nevada brothel.

He spent four days in a coma, and his estranged wife rushed to the hospital where he was being treated and temporarily called off their divorce proceedings.

She refiled for divorce once Odom had recovered and it was finalised in December 2016.

She is now expecting her first child with Cleveland Cavaliers star Tristan Thompson.