Wigan skipper Sean O'Loughlin justified his selection with two of his side's nine tries as the reigning champions comfortably broke their duck in the 2014 First Utility Super League with a 46-24 victory over Wakefield.
The England loose forward was one of just nine players retained from the team that lost the World Club Challenge to Sydney Roosters after persuading coach Shaun Wane not to rest him and he responded with a superb display.
O'Loughlin was withdrawn three minutes into the second half, with the Warriors 30-12 in front, and they continued to dominate in his absence, showing few signs of jetlag following their return from Australia.
Dom Manfredi and John Bateman both scored their first tries for Wigan while 19-year-old Joe Burgess, the only outside back to keep his place from Sydney, provided the highlight with a glorious long-range solo score.
The result leaves Wakefield without a win and it amounted to a double disappointment for chairman Michael Carter, a Sunderland fan who opted to go to Wembley rather than the DW Stadium.
Warrington registered their first victory of the season with a hard-earned 18-16 success against Hull FC at the Halliwell Jones Stadium.
The Wolves, pre-season favourites with some bookmakers to lift the title in October, had lost their opening two games against St Helens and Leeds but got off the mark at the third attempt as they held off a determined challenge from the visitors.
Wolves full-back Stefan Ratchford finished with a personal tally of 10 points after a try and three goals, while Warrington's other tries came from Trent Waterhouse and Ben Evans, with all the home side's points coming in the first half.
Hull, who have now suffered back-to-back defeats after their opening-day win over Catalan, replied with tries from Danny Houghton and Tom Lineham with Ben Crooks landing one conversion.
Fetuli Talanoa's try and a Crooks conversion three minutes from time reduced Warrington's lead to just two points to set up a grandstand finish but Lee Radford's side just could not peg the Wolves back.
Bradford pushed aside their mounting off-field troubles to claim their second win of the new season, triumphing 25-12 against London Broncos.
Luke Gale, Adam Sidlow, Danny Addy and Tom Olbison all crossed as the Bulls outscored their rivals four tries to two.
Thomas Minns and James Cunningham touched down for the Broncos, who fielded four debutants.
The Bulls were docked six points in midweek after entering administration for the second time and, while they remain bottom of the table, are now only two points behind a Broncos side tipped for relegation.