Jack Brooks continued his fine form with his second five-wicket haul at Headingley this season, as Lancashire nonetheless topped 300 for the first time in their LV= Division One campaign.
As with all the current round of championship fixtures, rain has had its say in the Roses clash.
But a tight tussle took place on day two regardless, Paul Horton (66) and Tom Smith (54) helping Lancashire to 325 all out despite the best efforts of Brooks (five for 90) and Liam Plunkett (four for 74).
Yorkshire then replied with 29 for none.
At Edgbaston, Somerset's fourth-wicket pair James Hildreth (98) and Nick Compton (92) both narrowly failed to complete their centuries in a stand nonetheless worth 163.
Thanks also to a maiden half-century from number 11 Jamie Overton (56), who put on 69 with his twin brother Craig, the visitors reached 411 all out despite three wickets for fit-again Warwickshire and England seamer Boyd Rankin.
The Bears were then 78 for one at stumps.
A rainy day at Trent Bridge restricted England's Stuart Broad to just six overs, in his first match of the season after resting his injured knee thus far.
He was wicketless as Durham replied to the hosts' 377 all out with 78 for two.
Table-toppers Middlesex saw day one of their match washed out at Northwood, where Sussex therefore had an extra 24 hours to decide whether England wicketkeeper Matt Prior's comeback from an Achilles injury would include duties behind as well as in front of the stumps.
In Division Two, rain also curtailed proceedings at Derby where David Wainwright had time to finish with an unbeaten 54 as the hosts moved from 166 for six to 278 all out against Gloucestershire - for whom Benny Howell took four for 60.
The reply reached 21 without loss before bad weather closed in.
There was even less play at Tunbridge Wells.
In reply to Kent's first-day 258, Worcestershire moved to 48 for none in the 14.1 overs possible.
Before an early finish at Chelmsford too, Surrey were able to move from 55 for three to 204 for six thanks to 63 from opener Arun Harinath.
Glamorgan consolidated their position of power at home to Leicestershire.
At stumps, they had piled up a first-innings lead of 241 on 350 for eight declared - opener Jacques Rudolph top-scoring with 88.
Doubtless with an eye on the weather forecast, the hosts then declared and were rewarded with more success as Leicestershire limped to six for one at stumps.